San Francisco 49ers vs Indianapolis Colts

San Francisco 49ers and Indianapolis Colts have met 5 times — San Francisco 49ers won 2, Indianapolis Colts won 3, with 0 draws. Their rivalry dates back to 2010. Indianapolis Colts leads the head-to-head with 3 victories from 5 meetings. A combined 266 goals have been scored across these fixtures, averaging 53.20 per match (143 for the home side, 123 for the visitors). Both teams scored in 5 matches (100%). Over 2.5 goals landed in 5 games (100%), making it a fixture that tends to produce goals. The highest-scoring encounter finished 27–48 in 2025.