Indianapolis Colts vs San Francisco 49ers

Indianapolis Colts and San Francisco 49ers have met 5 times — Indianapolis Colts won 4, San Francisco 49ers won 1, with 0 draws. Their rivalry dates back to 2013. Indianapolis Colts leads the head-to-head with 4 victories from 5 meetings. A combined 246 goals have been scored across these fixtures, averaging 49.20 per match (133 for the home side, 113 for the visitors). Both teams scored in 5 matches (100%). Over 2.5 goals landed in 5 games (100%), making it a fixture that tends to produce goals. The highest-scoring encounter finished 27–48 in 2025.