San Francisco 49ers vs Buffalo Bills

San Francisco 49ers and Buffalo Bills have met 3 times — San Francisco 49ers won 0, Buffalo Bills won 3, with 0 draws. Their rivalry dates back to 2016. Buffalo Bills leads the head-to-head with 3 victories from 3 meetings. A combined 164 goals have been scored across these fixtures, averaging 54.67 per match (50 for the home side, 114 for the visitors). Both teams scored in 3 matches (100%). Over 2.5 goals landed in 3 games (100%), making it a fixture that tends to produce goals. Buffalo Bills are currently unbeaten in the last 3 meetings. The highest-scoring encounter finished 45–16 in 2016.